Inhibition of mitochondrial respiration by analogs of 4-phenylpyridine and 1-methyl-4-phenylpyridinium cation (MPP+), the neurotoxic metabolite of MPTP-Reference-Cited by-同舟云学术

Inhibition of mitochondrial respiration by analogs of 4-phenylpyridine and 1-methyl-4-phenylpyridinium cation (MPP+), the neurotoxic metabolite of MPTP

Published:1987-10 Issue:2 Volume:148 Page:684-693
ISSN:0006-291X
Container-title:Biochemical and Biophysical Research Communications
language:en
Short-container-title:Biochemical and Biophysical Research Communications

Author:

Hoppel Charles L.,Greenblatt David,Kwok Hung-chi,Arora Pramod K.,Singh Malvinder P.,Sayre Lawrence M.

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference66 articles.

1. MPTP and parkinson's disease

2. The pharmacology of the parkinsonian syndrome producing neurotoxin MPTP (1–methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and structurally related compounds

3. Biochemistry of the neurotoxic action of MPTP: or how a faulty batch of ‘designer drug’ led to parkinsonism in drug abusers

4. Dopaminergic toxicity after the stereotaxic administration of the 1-methyl-4-phenylpyridinium ion (MPP+) to rats

5. Comparative toxicity of MPTP, MPP+ and 3,3-dimethyl-MPDP+ to dopaminergic neurons of the rat substantia nigra

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