The steroid antagonist RU38486 is metabolized by the liver microsomal P450 mono-oxygenases
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry,Biophysics
Reference21 articles.
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1. Therapeutic Drugs that Behave as Mechanism-Based Inhibitors of Cytochrome P450 3A4;Current Drug Metabolism;2004-10-01
2. In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone;The Journal of Steroid Biochemistry and Molecular Biology;2004-03
3. Mechanism-based inhibition of rat liver microsomal diazepam C3-hydroxylase by mifepristone associated with loss of spectrally detectable cytochrome P450;Chemico-Biological Interactions;1999-03
4. Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes;Biochemical Pharmacology;1996-09
5. Effects of food deprivation and adrenalectomy on CYP3A induction by RU486 in female rats;The Journal of Steroid Biochemistry and Molecular Biology;1996-07
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