Steric considerations regarding the biodegradation of cholesterol to pregnenolone.-exclusion of (22S)-22-hydroxycholesterol and 22-ketocholesterol as intermediates
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry,Biophysics
Reference12 articles.
1. Intermediates in the conversion of cholesterol to pregnenolone: Kinetics and mechanism
2. Enzymatic formation of (20R,22R)-20,22-dihydroxycholesterol from cholesterol and a mixture of 16O2 and 18O2: Random incorporation of oxygen atoms
3. Mass spectrometric study of the enzymatic conversion of cholesterol to (22R)-22-hydroxycholesterol, (20R,22R)-20,22-dihydroxycholesterol, and pregnenolone, and of (22R)-22-hydroxycholesterol to the lgycol and pregnenolone in bovine adrenocortical preparations. Mode of oxygen incorporation
4. Reassignment of Configuration to the 22-Hydroxycholesterols.Synthesis of (22s)- and (22R)-3H-Cholesterols
5. STERIC CONSIDERATIONS IN THE ENZYMATIC COURSE OF THE HYDROXYLATION OF STEROIDS*
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3. Quantum-Mechanical/Molecular-Mechanical Studies of CYP11A1-Catalyzed Biosynthesis of Pregnenolone from Cholesterol Reveal a C–C Bond Cleavage Reaction That Occurs by a Compound I-Mediated Electron Transfer;Journal of the American Chemical Society;2019-11-19
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5. Substrate Oxidation by Cytochrome P450 Enzymes;Cytochrome P450;2015
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