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Synthesis and Biological Evaluation of [11C]MK-912 as an α2-Adrenergic Receptor Radioligand for PET Studies

  • Published:1998-02 Issue:2 Volume:25 Page:127-133
  • ISSN:0969-8051
  • Container-title:Nuclear Medicine and Biology
  • language:en
  • Short-container-title:Nuclear Medicine and Biology

Author:

Shiue Chyng-yann,Pleus Richard C.,Shiue Grace G.,Rysavy Joseph A.,Sunderland John J.,Cornish Kurtis G.,Young Steven D.,Bylund David B.

Publisher

Elsevier BV

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Molecular Medicine

Reference58 articles.

1. α2-Agonist binding sites in brain;Alburges;Brain Res. Bull.,1993

2. Alpha-2-adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects;Arnsten;J. Neurosci.,1988

3. Aggregation of blood platelets by biogenic amines and its inhibition by antiadrenergic and antiserotonergic agents;Barthel;Biochem. Pharmacol.,1974

4. Preparation and in vivo binding of [11C]carazolol, a radiotracer for the beta-adrenergic receptor;Berridge;Nucl. Med. Biol.,1992

5. Quantitative in vitro and ex vivo autoradiography of the α2-adrenoceptor antagonist [3H]atipamezole;Biegon;Eur. J. Pharmacol.,1992
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