Efficient utilization of the reduced folate carrier in CCRF-CEM human leukemic lymphoblasts by the potent antifolate Nα-(4-amino-4-deoxypteroyl)-Nδ-hemiphthaloyl-l-ornithine (PT523) and its B-ring analogues

Author:

Wright Joel E,Vaidya Chitra M,Chen Ying-Nan,Rosowsky Andre

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference27 articles.

1. Methotrexate analogues. 33. Nδ-Acyl-Nα-(4-amino-4-deoxypteroyl)-l-ornithine derivatives;Rosowsky;J Med Chem,1988

2. Synthesis of the folylpolyglutamate synthetase inhibitor Nα-pteroyl-l-ornithine and its Nδ-benzoyl and Nδ-hemiphthaloyl derivatives, and an improved synthesis of Nα-(4-amino-4-deoxypteroyl)-Nδ-hemiphthaloyl-l-ornithine;Rosowsky;Pteridines,1989

3. Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells;Rhee;Mol Pharmacol,1994

4. Synthesis and biological activity of Nω-hemiphthaloyl-α,ω-diaminoalkanoic acid analogues of aminopterin and 3′,5′-dichloroaminopterin;Rosowsky;J Med Chem,1994

5. Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates;Chen;Mol Pharmacol,1995

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