Inhibition of human mast cell activation with the novel selective adenosine A2B receptor antagonist 3-isobutyl-8-pyrrolidinoxanthine (IPDX)22Abbreviations: cAMP, cyclic, AMP; DPCPX, 1,3-dipropyl-8-cyclopentylxanthine; DPSPX, 1,3-dipropyl-8-p-sulfophenylxanthine; FBS, fetal bovine serum; IB-MECA, N6 -(3-iodobenzyl)-N-methyl-5′-carbamoyladenosine; IL-8, interleukin-8; IPDX, 3-isobutyl-8-pyr,5rolidinoxanthine; NECA, 5′-N-ethylcarboxamidoadenosine; PDE, 3′,5′-cyclic nucleotide phosphodiesterase; SAR, structure-activity relationship.
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Published:2001-11
Issue:9
Volume:62
Page:1163-1173
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ISSN:0006-2952
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Container-title:Biochemical Pharmacology
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language:en
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Short-container-title:Biochemical Pharmacology
Author:
Feoktistov Igor,Garland Emily M.,Goldstein Anna E.,Zeng Dewan,Belardinelli Luiz,Wells Jack N.,Biaggioni Italo
Subject
Pharmacology,Biochemistry
Reference33 articles.
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4. Regulation of human basophil and lung mast cell function by cyclic adenosine monophosphate;Peachell;J Immunol,1988
5. Adenosine and asthma;Church;Trends Pharmacol Sci,1986
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