Enhanced activity of antisense phosphorothioate oligos against Leishmania amastigotes: augmented uptake of oligo, ribonuclease H activation, and efficient target intervention under altered growth conditions11Abbreviations: S-oligo, phosphorothioate oligodeoxyribonucleotide; ASM, anti-miniexon S-oligo; SSM, S-oligo complementary and anti-parallel to ASM; LUAS, anti-luciferase S-oligo; LUS, S-oligo complementary and anti-parallel to LUAS; MBSA, maleylated BSA; DMPC, dimyristoyl phosphatidylcholine; DMPE, dimyristoyl phosphatidylethanolamine; PLL, poly-l-lysine; and HIFBS, heat (56°)-inactivated fetal bovine serum.
Author:
Publisher
Elsevier BV
Subject
Pharmacology,Biochemistry
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