A rapid and simple HPLC–MS/MS method for the simultaneous quantification of valproic acid and its five metabolites in human plasma and application to study pharmacokinetic interaction in Chinese epilepsy patients-Reference-Cited by-同舟云学术

A rapid and simple HPLC–MS/MS method for the simultaneous quantification of valproic acid and its five metabolites in human plasma and application to study pharmacokinetic interaction in Chinese epilepsy patients

Published:2018-02 Issue: Volume:149 Page:448-456
ISSN:0731-7085
Container-title:Journal of Pharmaceutical and Biomedical Analysis
language:en
Short-container-title:Journal of Pharmaceutical and Biomedical Analysis

Author:

Wen Dingsheng,Chen Ziyi,Yang Chao,Liu Huanbin,Li Hongliang,Chen Juan,Dai Qiling,Zhong Guoping,Qin Jiaming,Ni Guanzhong,Huang Min,Zhou Liemin,Wang Xueding

Funder

National Science Foundation of China

Science and Technology Ministry of China

Major Scientific and Technological Project of Guangdong Province

Guangdong Provincial Key Laboratory of Construction Foundation

111 project

National Key Research and Development Program

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference19 articles.

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2. Role of the histone deacetylase inhibitor valproic acid in high-fat diet-induced hypertension via inhibition of HDA/angiotensin II axis;Choi;Int. J. Obes.,2005

3. Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents;Tan;J. Hematol. Oncol.,2010

4. Valproic acid and metabolites: pharmacological and toxicological studies;Nau;Epilepsia,1984

5. Influence of CYP2C9 genotypes on the formation of a hepatotoxic metabolite of valproic acid in human liver microsomes;Ho;Pharmacogen. J.,2003

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