An HPLC tandem mass spectrometry for quantification of ET-26-HCl and its major metabolite in plasma and application to a pharmacokinetic study in rats-Reference-Cited by-同舟云学术

An HPLC tandem mass spectrometry for quantification of ET-26-HCl and its major metabolite in plasma and application to a pharmacokinetic study in rats

Published:2018-02 Issue: Volume:149 Page:381-386
ISSN:0731-7085
Container-title:Journal of Pharmaceutical and Biomedical Analysis
language:en
Short-container-title:Journal of Pharmaceutical and Biomedical Analysis

Author:

Chen Xu,Zhang Wensheng,Rios Sandy,Morkos Miriam B.,Ye Xiaoli,Li Gen,Jiang Xuehua,Wang Zhijun,Wang Ling

Funder

National Science and Technology major projects “Significant Drug Discovery”

Neuroscience Research Center Anesthesia

Critical Emergency Research office at West China Hospital of Sichuan University

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference7 articles.

1. Evaluation of etomidate for seizure duration in electroconvulsive therapy: a systematic review and meta-analysis;Singh;J. ECT,2015

2. Pros and cons of etomidate–more discussion than evidence;van den Heuvel;Curr. Opin. Anaesthesiol.,2013

3. Etomidate is associated with mortality and adrenal insufficiency in sepsis: a meta-analysis;Chan;Crit. Care Med.,2012

4. An etomidate analogue with less adrenocortical suppression, stable hemodynamics, and improved behavioral recovery in rats;Wang;Anesth. Analg.,2017

5. Metabolite-inactive etomidate analogues alleviating suppression on adrenal function in Beagle dogs;Yang;Eur. J. Pharm. Sci.,2017

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Quantitative pharmacokinetic evaluation of Subtilisin QK-2 after a bolus IV injection in a rat model using a novel sandwich enzyme-linked immunosorbent assay;Journal of Pharmaceutical and Biomedical Analysis;2020-07

2. Non‐clinical single‐ and repeated‐dose toxicity studies of ET‐26 hydrochloride in rats;Journal of Applied Toxicology;2020-03-13

3. Metabolite identification, tissue distribution, excretion and preclinical pharmacokinetic studies of ET-26-HCl, a new analogue of etomidate;Royal Society Open Science;2020-02

4. Preclinical Pharmacokinetics Study of a Novel Intravenous Anesthetic ET-26 Hydrochloride;Current Drug Metabolism;2020-01-23

5. Preclinical safety evaluation of ET‐26 hydrochloride, a novel intravenous anesthetic agent, in beagle dogs;Journal of Applied Toxicology;2019-12-22