Integrated UHPLC-MS untargeted metabolomics and gut microbe metabolism pathway-targeted metabolomics to reveal the prevention mechanism of Gushudan on kidney-yang-deficiency-syndrome rats

Author:

Xin Ling,Ren Mengxin,Lou Yanwei,Yin Huawen,Qin Feng,Xiong Zhili

Funder

National Natural Science Foundation of China

Publisher

Elsevier BV

Reference35 articles.

1. Study on the substance basis of the efficacy of eucommiae cortex before and after salt processing for the treatment of kidney-yang deficiency syndrome based on the spectrum-effect relationship;Wu;J. Ethnopharmacol.,2024

2. Analysis of gene expression and functional changes of adrenal gland in a rat model of kidney yang deficiency syndrome treated with Sini decoction;Tang;Exp. Ther. Med.,2018

3. Fecal metabonomics combined with 16S rRNA gene sequencing to analyze the changes of gut microbiota in rats with kidney-yang deficiency syndrome and the intervention effect of You-gui pill;Chen;J. Ethnopharmacol.,2019

4. You-Gui-Yin improved the reproductive dysfunction of male rats with chronic kidney disease via regulating the HIF1 alpha-STAT5 pathway;Li;J. Ethnopharmacol.,2020

5. Urine metabonomic study of intervention effects of Morinda officinalis how on'kidney-yang deficiency syndrome';Zou;Yao xue xue bao= Acta Pharm. Sin.,2013

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