Simultaneous LC-MS/MS quantification of oxycodone, tramadol and fentanyl and their metabolites (noroxycodone, oxymorphone, O- desmethyltramadol, N- desmethyltramadol, and norfentanyl) in human plasma and whole blood collected via venepuncture and volumetric absorptive micro sampling

Author:

Al-Qurain Aymen A.ORCID,Williams Desmond B.,Mackenzie Lorraine,Roberts Michael S.,Wiese Michael D.

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference23 articles.

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3. Pharmacokinetic and pharmacodynamic changes in the elderly;Hammerlein;Clin. Implications Clin. Pharmacokinet.,1998

4. Clinical pharmacokinetic considerations in the elderly. An update;Kinirons;Clin. Pharmacokinet.,1997

5. Opioid metabolism and effects of cytochrome P450;Holmquist;Pain Med.,2009

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