Simultaneous characterization of insulin HMWP and protamine sulphate in complex formulations through SEC-coupled mass spectrometry
Author:
Publisher
Elsevier BV
Subject
Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry
Reference23 articles.
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2. Strategies for the assessment of protein aggregates in pharmaceutical biotech product development;den Engelsman;Pharm. Res.,2011
3. Chemical stability of insulin. 5. Isolation, characterization and identification of insulin transformation products;Brange;Acta Pharm. Nord.,1992
4. Type 2 diabetes as a protein misfolding disease;Mukherjee;Trends Mol. Med.,2015
5. Structure, aggregation, and activity of a covalent insulin dimer formed during storage of neutral formulation of human insulin;Hjorth;J. Pharm. Sci.,2016
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