Separation and identification of a complex flurbiprofen-polyethylene glycol mono- and diester mixture via a hyphenated HPLC-DAD-HRMS/SPE NMR system

Author:

Schmidt Philipp,Kolb Christine,Godejohann Markus,Reiser Andreas,Philipp Markus,Müller Hans-Christian,Karaghiosoff Konstantin

Funder

Hexal AG

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference32 articles.

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3. Physiology and treatment of pain and inflammation: analgesic effects of flurbiprofen;Kantor;Am. J. Med.,1986

4. K. Sawicka, J. Takhar, P. Marrshall, M. Fanfarillo, Production Process for NSAID-Containing Lozenges, Their Compositions, Their Medical Use. WO 2006/092569 A1, September 8, 2006.

5. Ester prodrugs of flurbiprofen: Synthesis, plasma hydrolysis and gastrointestinall toxicity;Mohan;Indian J. Chem.,2007

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