Heparin sodium compliance to the new proposed USP monograph: Elucidation of a minor structural modification responsible for a process dependent 2.10ppm NMR signal-Reference-Cited by-同舟云学术

Heparin sodium compliance to the new proposed USP monograph: Elucidation of a minor structural modification responsible for a process dependent 2.10ppm NMR signal

Published:2011-01 Issue:2 Volume:54 Page:337-344
ISSN:0731-7085
Container-title:Journal of Pharmaceutical and Biomedical Analysis
language:en
Short-container-title:Journal of Pharmaceutical and Biomedical Analysis

Author:

Mourier Pierre A.J.,Guichard Olivier Y.,Herman Fréderic,Viskov Christian

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference9 articles.

1. Heparin sodium monograph in pharmacopeial forum, vol. 35(5) [Sept–Oct 2009] p. 3. 1H NMR spectrum. Signal 1 is observed at 5.42ppm (H1 of GlcNAc/GlcNS,6S) and signal 2 at 5.21ppm (H1 of IdoA 2S). The ppm values of these signal should not differ by more than +0.03ppm.

2. ,Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events;Guerrini;Nat. Biotechnol.,2008

3. Chromatographic analysis and sequencing approach of heparin oligosaccharides using cetyltrimethylammonium dynamically coated stationary phases;Mourier;Anal. Biochem.,2004

4. Liquid chromatography/mass spectrometry sequencing approach for highly sulfated heparin-derived oligosaccharides;Thanawiroon;J. Biol. Chem.,2004

5. A general enhancement scheme in heteronuclear multidimensional NMR employing pulsed field gradients;Schleucher;Biomol. NMR,1994

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