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Pharmacokinetics of 40 kDa PEG in rodents using high-field NMR spectroscopy

  • Published:2019-07 Issue: Volume:171 Page:30-34
  • ISSN:0731-7085
  • Container-title:Journal of Pharmaceutical and Biomedical Analysis
  • language:en
  • Short-container-title:Journal of Pharmaceutical and Biomedical Analysis

Author:

Khandelwal Purnima,Zhang Lisa,Chimalakonda Anjaneya,Caceres-Cortes Janet,Huang Christine,Marathe Punit,Reily Michael D.

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference28 articles.

1. Introduction and overview of peptide and protein pegylation;Veronese;Adv. Drug Deliv. Rev.,2002

2. Modulation of the pharmacokinetics and pharmacodynamics of proteins by polyethylene glycol conjugation;Mehvar;J. Pharm. Pharm. Sci.,2000

3. The pharmacology of PEGylation: balancing PD with PK to generate novel therapeutics;Fishburn;J. Pharm. Sci.,2008

4. FDA-approved poly(ethylene glycol)–protein conjugate drugs;Alconcel;Polym. Chem.,2011

5. Clinical trial: single- and multiple-dose pharmacokinetics of polyethylene glycol (PEG-3350) in healthy young and elderly subjects;Pelham;Aliment. Pharmacol. Ther.,2008
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