Validated LC–MS/MS method for the determination of amlodipine enantiomers in rat plasma and its application to a stereoselective pharmacokinetic study

Author:

Wang Lijuan,Liu Wenxia,Zhang Zunjian,Tian Yuan

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference33 articles.

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2. Australian Government, Department of Health Therapeutic Goods Administration, AusPAR: Olmesartan medoxomil/Amlodipine besylate, 2010-09-21. https://www.tga.gov.au/sites/default/files/auspar-sevikar.pdf.

3. Rapid quantification of amlodipine enantiomers in human plasma by LC-MS/MS: application to a clinical pharmacokinetic study;Hotha;Biomed. Chromatogr. Bmc,2013

4. Simultaneous enantioseparation and purity determination of chiral switches of amlodipine and atenolol by liquid chromatography;Kannappan;J. Pharm. Biomed. Anal.,2015

5. Changes of action potential and L-type calcium channel current of Sprague-Dawley rat ventricular myocytes by different amlodipine isomers;Wang;Can. J. Physiol. Pharmacol.,2008

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