Investigation of the mechanism of incompatible herb pair gansui-gancao-induced hepatotoxicity and nephrotoxicity and the attenuated effect of gansuibanxia decoction by UHPLC-FT-ICR-MS-based plasma metabonomic analysis

Author:

Cui Yue,Wang Roujia,Zhang Ye,Liu Ting,Han Fei,Li Ruiyun,Zhang Nan,Zhao Yunli,Yu Zhiguo

Funder

the Project for National Basic Science Personnel Training Fund

the National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference30 articles.

1. A systems biology-based investigation into the therapeutic effects of Gansui Banxia Tang on reversing the imbalanced network of hepatocellular carcinoma;Zhang;Sci. Rep.,2014

2. The research about the effect of the eighteen incompatible medicaments coordinated use of glycyrrhiza with euphorbia and Gansui Banxia decoction in organ and biochemical indexes of rats;Wang;J. Shanxi Colg. of Tradit. Chin. Med.,2018

3. Effect of licorice and kansui combination on the functions and pathological histomorphology of heart, liver and kidney in rat;Huang;Chin. J. Clin. Rehab.,2004

4. Simultaneous determination of five bioactive components of Gancao in rat plasma by UHPLC-MS/MS and its application to comparative pharmacokinetic study of incompatible herb pair Gansui-Gancao and Gansuibanxia Decoction;Cui;J. Pharm. Biomed. Anal.,2018

5. Understanding ‘global’ systems biology: metabonomics and the continuum of metabolism;Nicholson;Nat. Rev.,2003

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