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UHPLC-HRMS study of anti-Alzheimer’s drug candidates: metabolism of 7-MEOTA-tryptophan hybrids hampers their passage into brain

  • Published:2019-09 Issue: Volume:174 Page:134-144
  • ISSN:0731-7085
  • Container-title:Journal of Pharmaceutical and Biomedical Analysis
  • language:en
  • Short-container-title:Journal of Pharmaceutical and Biomedical Analysis

Author:

Mžik M.,Žďárová-Karasová J.,Chalupová K.,Korábečný J,Palička V.,Šesták V.

Funder

Grant Agency of the Czech Republic

University of Defence (Long Term Development Plan) Czech Republic

MH CZ - DRO (University Hospital Hradec Kralove

COST Action CA1513

Ministry of Education

Youth and Sports of Czech Republic

program SVV

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference34 articles.

1. Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013;Abubakar;Lancet,2015

2. Alzheimer’s disease;Querfurth;N. Engl. J. Med.,2010

3. Two decades of new drug discovery and development for Alzheimer’s disease;Liu;RSC Adv.,2017

4. Outcomes of Alzheimer’s disease therapy with acetylcholinesterase inhibitors and memantine;Zemek;Expert Opin. Drug Saf.,2014

5. Tacrine (THA, Cognex(R));Summers;J. Alzheimers Dis.,2000

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