Formation of the diuretic chlorazanil from the antimalarial drug proguanil—Implications for sports drug testing

Author:

Thevis Mario,Geyer Hans,Thomas Andreas,Tretzel Laura,Bailloux Isabelle,Buisson Corinne,Lasne Francoise,Schaefer Maximilian S.,Kienbaum Peter,Mueller-Stoever Irmela,Schänzer Wilhelm

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference24 articles.

1. Amides, amines and related compounds as diuretics;Lipschitz;J. Pharmacol. Exp. Ther.,1944

2. Comparison of effects of various diuretics with special consideration of N-p-chlorophenyl-2,4-diamino-S-triazine (orpidan);Kühn;Klin. Wochenschr.,1957

3. Observations on the diuretic effect of orpidan;Esch;Klin. Wochenschr.,1957

4. World Anti-Doping Agency. 2013 Anti-Doping Testing Figures 2015, https://www.wada-ama.org/en/resources/laboratories/2013-anti-doping-testing-figures-laboratory-report (27-05-2015).

5. Simultaneous determination of chloroquine, proguanil and their metabolites in human biological fluids by high-performance liquid chromatography;Chaulet;J. Pharm. Biomed. Anal.,1994

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