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Tapentadol enantiomers: Synthesis, physico-chemical characterization and cyclodextrin interactions

  • Published:2014-01 Issue: Volume:88 Page:594-601
  • ISSN:0731-7085
  • Container-title:Journal of Pharmaceutical and Biomedical Analysis
  • language:en
  • Short-container-title:Journal of Pharmaceutical and Biomedical Analysis

Author:

Fejős Ida,He Yang,Völgyi Gergely,Kazsoki Adrienn,Sun Jin,Chen Weiming,Sohajda Tamás,Szente Lajos,Jiang Xiangrui,Béni Szabolcs

Funder

OTKA PD

Hungarian Academy of Sciences

National Science and Technology Major Project

Key Project of Science and Technology of Shanghai

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference23 articles.

1. The neuropathic pain market;Nightingale;Nat. Rev. Drug Discov.,2012

2. (−)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride (tapentadol:HCl): a novel μ-opioid receptor agonist/norepinephrine reuptake inhibitor with broad-spectrum analgesic properties;Tzschentke;J. Pharmacol. Exp. Ther.,2007

3. Absorption and Drug Development: Solubility, Permeability and Charge State;Avdeef,2012

4. Physico-chemical Methods in Drug Discovery and Development;Takács-Novák,2012

5. Fundamental study of enantioselective HPLC separation of tapentadol enantiomers using cellulose-based chiral stationary phase in normal phase mode;Douša;J. Pharm. Biomed. Anal.,2013

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