LC-HRMS and NMR studies for the characterization of degradation impurities of ubrogepant along with the in silico approaches for the prediction of degradation and toxicity

Author:

Chaganti Sowmya,Chauhan Usha,Bhatt Nehal,Kommalapati Hemasree,Golla Vijaya Madhyanapu,Pilli Pushpa,Samanthula Gananadhamu

Publisher

Elsevier BV

Reference28 articles.

1. Calcitonin gene-related peptide: physiology and pathophysiology;Russell;Physiol. Rev.,2014

2. Characterisation of the calcitonin gene-related peptide receptor antagonists ubrogepant and atogepant in human isolated coronary, cerebral and middle meningeal arteries;Rubio-Beltran;Cephalalgia,2020

3. Ubrogepant: first approval;Scott;Drugs,2020

4. USFDA, UBRELVY (ubrogepant) tablets, for oral use. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211765s000lbl.pdf (Accessed date: January, 2024).

5. National Center for Biotechnology Information. PubChem Compound Summary for CID 68748835, Ubrogepant. https://pubchem.ncbi.nlm.nih.gov/compound/Ubrogepant, (Accessed date: 17 January, 2024).

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