Simultaneous determination of Pyragrel, a novel anti-thrombotic agent, and its two primary metabolites in plasma by HPLC–MS/MS-Reference-Cited by-同舟云学术

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Simultaneous determination of Pyragrel, a novel anti-thrombotic agent, and its two primary metabolites in plasma by HPLC–MS/MS

Published:2018-07 Issue: Volume:156 Page:199-205
ISSN:0731-7085
Container-title:Journal of Pharmaceutical and Biomedical Analysis
language:en
Short-container-title:Journal of Pharmaceutical and Biomedical Analysis

Author:

Yang Guoping,Pei Qi,Fu Chengxiao,Huang Jie,Chen Jun,Yang Shuang,Xiang Yuxia,Wang Jing,Tan Hongyi,Liu Xiaolei

Funder

Program for The New Xiangya Talent Projects of the Third Xiangya Hospital of Central South University

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference8 articles.

1. MC-002 exhibits positive effects against platelets aggregation and endothelial dysfunction through thromboxane A2 inhibition;Fang;Thromb. Res.,2014

2. Thromboxane: prostacyclin, and leukotrienes in cerebral ischemia;Chen;Neurology,1986

3. Accumulation of arachidonic acid cyclo- and lipoxygenase products in rat brain during ischemia and reperfusion: effects of treatment with GM1-lactone;Petroni;J. Neurochem.,1989

4. A selective thromboxane A2 (TXA2) synthase inhibitor: ozagrel, attenuates lung injury and decreases monocyte chemoattractant protein-1 and interleukin-8 mRNA expression in oleic acid-induced lung injury in guinea pigs;Ishitsuka;J. Pharmacol. Sci.,2009

5. Human thromboxane synthase: comparative modeling and docking evaluation with the competitive inhibitors Dazoxiben and Ozagrel;Sathler;J. Enzyme Inhib. Med. Chem.,2014

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3. Phase I Trial of Pyragrel, a Novel Thromboxane Synthetase Inhibitor, to Evaluate the Safety, Tolerability, and Pharmacokinetics in Healthy Volunteers;Frontiers in Pharmacology;2019-10-24

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