A sensitive assay for the determination of E7090, a novel selective inhibitor of fibroblast growth factor receptors, and its metabolite in human plasma by UPLC-MS/MS with at-column dilution

Author:

Mano YujiORCID,Nitanai Ikumi,Hotta Koichiro

Funder

Eisai Incorporated

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference8 articles.

1. E7090, a Novel Selective Inhibitor of Fibroblast Growth Factor Receptors, Displays Potent Antitumor Activity and Prolongs Survival in Preclinical Models;Watanabe Miyano;Mol. Cancer Ther.,2016

2. First-in-human phase I study of E7090, a novel selective fibroblast growth factor receptor inhibitor, in patients with advanced solid tumors;Koyama;Cancer Sci.,2020

3. A validated UPLC-MS/MS assay of E7090, a novel selective inhibitor of fibroblast growth factor receptors, in human plasma and urine;Asakawa;J. Pharm. Biomed. Anal.,2022

4. At-Column-Dilution, Application Notes from Waters (At-Column-Dilution, Application Note (71500078010EN), Revision A. 2003. 〈https://www.waters.com/webassets/cms/library/docs/71500078010rA_AppNotes.pdf〉. (Accessed: 9 March 2022).

5. A method for the direct injection and analysis of small volume human blood spots and plasma extracts containing high concentrations of organic solvents using revered-phase 2D UPLC/MS;Rainville;Analyst,2015

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