Pharmacokinetics, bioavailability, excretion, and metabolic analysis of Schisanlactone E, a bioactive ingredient from Kadsura heteroclita (Roxb) Craib, in rats by UHPLC–MS/MS and UHPLC-Q-Orbitrap HRMS

Author:

Liu Rongxia,Liu Qianqian,Li Bin,Liu Leping,Cheng Dongsheng,Cai Xiong,Liu Wanhui,Wang Wei

Funder

National Natural Science Foundation of China

Taishan and Furong Scholar Projects

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference24 articles.

1. Tujia ethnomedicine Xuetong suppresses onset and progression of adjuvant-induced arthritis in rats;Yu;Chin. Pharmacol. Bull.,2016

2. Analgesic and anti-inflammatory effects and molecular mechanisms of Kadsura heteroclita stems, an anti-arthritic Chinese Tujia ethnomedicinal herb;Yu;J. Ethnopharmacol.,2019

3. Kadsura heteroclita stem suppresses the onset and progression of adjuvant-induced arthritis in rats;Yu;Phytomedicine,2019

4. Pharmacodynamics of alien kadsura total triterpenes used for anti-inflammatory analgesia in mice suffering from rheumatoid arthritis;Deng;Anhui Med. Pharm. J.,2016

5. Study on the interference of total triterpenes of heterogenous Schisandra on anti-infl ammatory target in rats with rheumatoid arthritis;Deng;Rheum. Arthritis,2018

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