First-in-human study to assess the safety, tolerability, and pharmacokinetics of intravenous SHPL-49 following single- and multiple-ascending-dose administration in healthy adults-Reference-Cited by-同舟云学术

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First-in-human study to assess the safety, tolerability, and pharmacokinetics of intravenous SHPL-49 following single- and multiple-ascending-dose administration in healthy adults

Published:2024-10 Issue: Volume:249 Page:116314
ISSN:0731-7085
Container-title:Journal of Pharmaceutical and Biomedical Analysis
language:en
Short-container-title:Journal of Pharmaceutical and Biomedical Analysis

Author:

Li Shuya,Yang Cuicui,Wang Weicong,Li Jian,Xu Shuhong,Zhao Min,Xu Chunmin,Wang Jiaqing,Wang Yongjun

Publisher

Elsevier BV

Reference22 articles.

1. R.H.C. Lee, M.H.H. Lee, C.Y.C. Wu, et al. Cerebral ischemia and neuroregeneration [published correction appears in Neural Regen Res. 2022 Aug;17(8):1639]. Neural Regen Res. 2018;13(3):373-385. doi:10.4103/1673-5374.228711.

2. Excitatory synaptic transmission in ischemic stroke: a new outlet for classical neuroprotective strategies;Wang;Int. J. Mol. Sci.,2022

3. Interpretation and considerations on the safety evaluation of human drug metabolites;Atrakchi;Chem. Res. Toxicol.,2009

4. Thrombolytic tPA-induced hemorrhagic transformation of ischemic stroke is mediated by PKCβ phosphorylation of occludin;Goncalves;Blood,2022

5. Glutamate-releasing BEST1 channel is a new target for neuroprotection against ischemic stroke with wide time window;Xiong;Acta Pharm. Sin. B,2023

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