A single-nucleotide resolution capillary gel electrophoresis workflow for poly(A) tail characterization in the development of mRNA therapeutics and vaccines

Author:

Di Grandi Deanna,Dayeh Daniel M.,Kaur Keerat,Chen Yizhuo,Henderson Steven,Moon Youmi,Bhowmick Arijit,Ihnat Peter M.,Fu Yue,Muthusamy Kathir,Palackal Nisha,Pyles Erica A.

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference30 articles.

1. mRNA vaccines for infectious diseases: principles, delivery and clinical translation;Chaudhary;Nat. Rev. Drug Discov.,2021

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3. Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression;Passmore;Nat. Rev. Mol. Cell Bio,2022

4. mRNA vaccines in the COVID-19 pandemic and beyond;Hogan;Annu. Rev. Med,2021

5. mRNA-based therapeutics — developing a new class of drugs;Sahin;Nat. Rev. Drug Discov.,2014

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