Clonidine complexation with hydroxypropyl-beta-cyclodextrin: From physico-chemical characterization to in vivo adjuvant effect in local anesthesia

Author:

Braga M.A.,Martini M.F.,Pickholz M.,Yokaichiya F.,Franco M.K.D.,Cabeça L.F.,Guilherme V.A.,Silva C.M.G.,Limia C.E.G.,de Paula E.ORCID

Funder

FAPESP

CNPq

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference64 articles.

1. Clonidine: from nasal decongestive to potent analgesic: hystorical and pharmacological considerations;Simonetti;Rev. Bras. Anestesiol.,1997

2. Meta-analysis of the efficacy of extradural clonidine to relieve postoperative pain: an impossible task;Armand;Br. J. Anaesth.,1998

3. Should we add clonidine to local anesthetic for peripheral nerve blockade? a qualitative systematic review of the literature;MacCartney;Reg. Anesth. Pain Med.,2007

4. Clonidine as an adjuvant to intrathecal local anesthetics for surgery: systematic review of randomized trials;Elia;Reg. Anesth. Pain Med.,2008

5. Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials;Pöpping;Anesthesiology,2009

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