LC and LC–MS/MS studies for identification and characterization of new degradation products of ibrutinib and elucidation of their degradation pathway

Author:

Mehta Lovekesh,Naved Tanveer,Grover Parul,Bhardwaj Monika,Mukherjee Debaraj

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference14 articles.

1. Ibrutinib: an evidence-based review of its potential in the treatment of advanced chronic lymphocytic leukemia;Chavez;Core Evid.,2013

2. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy;Honigberg;Proc. Natl. Acad. Sci.,2010

3. Ibrutinib: implications for use in the treatment of mantle cell lymphoma and chronic lymphocytic leukemia;McNally;J. Adv. Pract. Oncol.,2015

4. Disruption of in vivo chronic lymphocytic leukemia tumor–microenvironment interactions by ibrutinib–findings from an investigator-initiated phase II study;Niemann;Clin. Cancer Res.,2016

5. Ibrutinib inhibits BCR and NF-κB signaling and reduces tumor proliferation in tissue-resident cells of patients with CLL;Herman;Blood J. Am. Soc. Hematol.,2014

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