Rapid characterization of the potential active metabolites of diacerein in rat plasma based on UHPLC-Q-exactive orbitrap mass spectrometry and molecular docking

Author:

Li Kailin,Liu Mingjuan,Zhang Min,Li Qing,Yu Kaiquan,Li Jiaxin,Shang Zichao,Cai Wei

Funder

Science and Technology Program of Hunan Province

Hunan Provincial Science and Technology Department

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference40 articles.

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3. Contribution of salidroside to the relieve of symptom and sign in the early acute stage of osteoarthritis in rat model;Sa;J. Ethnopharmacol.,2020

4. Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis;Wei;Mol. Med. Rep.,2018

5. Application of MBTH and sulphanilic acid for the quantitative spectrophotometric determination of diacerein in bulk and formulations;Raja;Der Pharma Chem.,2009

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