A method combining blue native polyacrylamide gel electrophoresis with liquid chromatography tandem-mass spectrometry to detect circulating immune complexes between therapeutic monoclonal antibodies and anti-drug antibodies in animals

Author:

Kobayashi Kazuhiro,Tahara Harunobu,Kagawa Yoshiyuki

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference28 articles.

1. Developments in therapy with monoclonal antibodies and related proteins;Shepard;Clin. Med.: J. R. Coll. Physicians London.,2017

2. Antibodies to watch in 2020;Kaplon;MAbs.,2020

3. Immunogenicity/Hypersensitivity of biologics;Leach;Toxicol. Pathol.,2014

4. The impact of anti-drug antibodies on drug concentrations and clinical outcomes in rheumatoid arthritis patients treated with adalimumab, etanercept, or infliximab: results from a multinational, real-world clinical practice, non-interventional study;Moots;PLoS One,2017

5. Anti-therapeutic antibodies and their clinical impact in patients treated with the TNF antagonist adalimumab;Cludts;Cytokine,2017

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