Norelgestromin/ethinyl estradiol intravenous infusion formulation optimization, stability and compatibility testing: A case study to overcome polysorbate 80 interference in chromatographic analysis

Author:

Abdallah Inas A.,Hammell Dana C.,Hassan Hazem E.,Stinchcomb Audra L.

Funder

Food and Drug Administration

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference34 articles.

1. Pharmacokinetics of a contraceptive patch (Ortho Evra) containing norelgestromin and ethinyloestradiol at four application sites;Abrams;Br. J. Clin. Pharmacol.,2002

2. Simultaneous determination of ethinyl estradiol and drospirenone in oral contraceptive by high performance liquid chromatography;Silva;Braz. J. Pharm. Sci,2013

3. Development and validation of a simple and sensitive RP-HPLC method for simultaneous estimation of drospirenone and ethinylestradiol in combined tablet dosage form;Warkad;Int. J. Pharm. Pharm. Sci.,2012

4. Determination of levonorgestrel and ethinyl estradiol in pharmaceutical formulations by H-point standard addition method in nonaqueous solvent using simultaneous addition of both analytes;Ahmadi;J. Rep. Pharm. Sci.,2012

5. Determination of norelgestromin in rabbit plasma by LC–MS/MS and its application to the pharmacokinetic study of ORTHO EVRA;Liu;J. Chromatogr. B Anal. Technol. Biomed. Life Sci.,2009

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