Structure and pharmaceutical formulation development of a new long-acting recombinant human insulin analog studied by NMR and MS

Author:

Bednarek Elżbieta,Sitkowski Jerzy,Bocian Wojciech,Borowicz Piotr,Płucienniczak Grażyna,Stadnik Dorota,Surmacz-Chwedoruk Weronika,Jaworska Beata,Kozerski Lech

Funder

National Centre of Research and Development

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference19 articles.

1. Design of ultra-stable insulin analogues for the developing world;Weiss;J. Health Spec.,2013

2. NMR structure of biosynthetic engineered human insulin monomer B31Lys-B32Arg in water/acetonitrile solution. Comparison with the solution structure of native human insulin monomer;Bocian;Biopolymers,2008

3. P. Borowicz, A. Płucienniczak, J. Mikołajczyk, T. Głąbski, D. Kurzynoga, D. Mikiewicz-Syguła, A. Wojtowicz-Krawiec, M. Zieliński, M. Kęsik-Brodacka, V. Adamczewska-Cecuda, I. Sokołowska, G. Płucienniczak, D. Stadnik, J. Antosik, J. Pstrzoch, J. Bernat, W. Sławiński, T. Pawlukowiec, J. Stępniewski, M. Bogiel, Novel insulin analogues of prolonged activity, Institute of Biotechnology and Antibiotics, Patent. Poland (2009).

4. Recombinant A22(G)-B31 (R)-human insulin. A22 addition introduces conformational mobility in B chain C-terminus;Borowicz;J. Biomol. NMR,2012

5. Biosynthetic engineered B28(K)-B29(P) human insulin monomer structure in water and in water/acetonitrile solutions;Borowicz;J. Biomol. NMR,2013

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