Simple and sensitive LC–MS/MS method for simultaneous determination of crizotinib and its major oxidative metabolite in human plasma: Application to a clinical pharmacokinetic study
Author:
Publisher
Elsevier BV
Subject
Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry
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3. Structure based drug design of crizotinib (PF-02341066) a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase, (ALK);Cui;J. Med. Chem.,2011
4. Gender specific drug metabolism of PF-02341066 in rats-role of sulfoconjugation;Zhong;Curr. Drug Metab.,2010
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2. Simultaneous determination of unecritinib (TQ-B3101) and its active metabolite crizotinib in rat plasma by LC-MS/MS:An application to pharmacokinetic studies;Journal of Pharmaceutical and Biomedical Analysis;2024-08
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4. Crizotinib: A comprehensive profile;Profiles of Drug Substances, Excipients and Related Methodology;2023
5. Development and validation of a novel LC-MS/MS method for simultaneous quantitative determination of tyrosine kinase inhibitors in human plasma;Journal of Chromatography B;2022-10
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