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A facile one-step fluorescence method for the quantitation of low-content single base deamination impurity in synthetic oligonucleotides

  • Published:2018-06 Issue: Volume:155 Page:50-55
  • ISSN:0731-7085
  • Container-title:Journal of Pharmaceutical and Biomedical Analysis
  • language:en
  • Short-container-title:Journal of Pharmaceutical and Biomedical Analysis

Author:

Su Xiaoye,Liang Ruiting,Stolee Jessica A.

Funder

Analytical Development and Antisense Oligonucleotide Development groups at Biogen, Cambridge, MA

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference20 articles.

1. Biotech comes to its ‘antisenses' after hard-won drug approval;Jiang;Nat. Med.,2013

2. DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing;Nishina;Nat. Commun.,2015

3. Managing the sequence-specificity of antisense oligonucleotides in drug discovery;Hagedorn;Nucleic Acids Res.,2017

4. Guidance for industry Q3A impurities in new drug substances;U.S. Food and Drug Administration −International Conference of Harmonisation,2003

5. Hydrolytic deamination of 5-methylcytosine in protic medium: a theoretical study;Labet;J. Phys. Chem. A,2009

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