Heparin sodium compliance to USP monograph: Structural elucidation of an atypical 2.18ppm NMR signal

Author:

Mourier Pierre A.J.,Guichard Olivier Y.,Herman Fréderic,Viskov Christian

Funder

Sanofi

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference19 articles.

1. Heparin Sodium Monograph in Pharmacopeial Forum, vol. 35 (5), 1H NMR Spectrum, September–October 2009, p. 1–4.

2. Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events;Guerrini;Nat. Biotechnol.,2008

3. Quality assessment of unfractionated heparin using 1H nuclear magnetic resonance spectroscopy;Beyer;J. Pharm. Biomed. Anal.,2008

4. Determination of oversulphated chondroitin sulphate and dermatan sulphate in unfractionated heparin by 1H-NMR—collaborative study for quantification and analytical determination of LoD;McEwen;Pharmeuropa Bio,2008

5. Broadening of 1H NMR signals in the spectra of heparin and OSCS by paramagnetic transition metal ions. The use of EDTA to sharpen the signals;McEwen;J. Pharm. Biomed. Anal.,2010

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