Simultaneous quantification of tafetinib (SIM010603), a novel potent inhibitor of receptor tyrosine kinase, and its major metabolite in dog plasma by HPLC–ESI/MS/MS and its application to a pharmacokinetic study

Author:

Shao Feng,Zhu Tian,Tang Feng,Liu Xin

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference15 articles.

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3. Sunitinib malate for the treatment of solid tumours: a review of current clinical data;Motzer;Expert Opin. Investig. Drugs,2006

4. Sunitinib malate;Atkins;Nat. Rev. Drug Discov.,2006

5. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship;Mendel;Clin. Cancer Res.,2003

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