Identification of oxidative degradation impurities of Olanzapine drug substance as well as drug product

Author:

Rao P. Sreenivasa,Ray Uttam Kumar,Hiriyanna S.G.,Rao Sumathi V.,Sharma Hemant Kumar,Handa Vijay Kumar,Mukkanti K.

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference14 articles.

1. 4-piperazinyl-10H-thieno[2,3-b][1,5]benzodiazepines as potential neuroleptics;Chakrabarti;J. Med. Chem.,1980

2. 10-piperazinyl-4H-thieno[2,3-b][1,5]benzodiazepines as potential neuroleptics;Chakrabarti;J. Med. Chem.,1980

3. The synthesis and biological activity of some known and putative metabolites of the atypical antipsychotic agent Olanzapine (LY170053);Calligaro;Bioorg. Med. Chem. Lett.,1997

4. J.K. Chakrabarti, D.E. Tupper, Thieno[1,5]benzodiazepines, Ger. Offen 2,552,403 (CA 86: 29893e).

5. C.J. Kumar, H.T. Michael, T.D. Edward, Preparation of 2-methyl-4-(4-methyl-1-piperzinyl)-10H-thieno[2,3-b][1,5]benzodiazepine, Eur. Pat. Appl. EP 454,436 (CA 116: 83703u).

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