Population model analysis of chiral inversion and degradation of bupropion enantiomers, and application to enantiomer specific fraction unbound determination in rat plasma and brain-Reference-Cited by-同舟云学术

Population model analysis of chiral inversion and degradation of bupropion enantiomers, and application to enantiomer specific fraction unbound determination in rat plasma and brain

Published:2021-02 Issue: Volume:195 Page:113872
ISSN:0731-7085
Container-title:Journal of Pharmaceutical and Biomedical Analysis
language:en
Short-container-title:Journal of Pharmaceutical and Biomedical Analysis

Author:

Bhattacharya Chandrali^ORCID,Masters Andrea R.,Bach Christine,Stratford Robert E.^ORCID

Funder

National Center for Advancing Translational Sciences

Indiana University

National Institutes of Health

Indiana Clinical and Translational Sciences Institute

National Cancer Institute

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference22 articles.

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3. Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors;Damaj;Mol. Pharmacol.,2004

4. Chiral plasma pharmacokinetics and urinary excretion of bupropion and metabolites in healthy volunteers;Masters;J. Pharmacol. Exp. Ther.,2016

5. Stereoselective metabolism of bupropion by cytochrome P4502B6 (CYP2B6) and human liver microsomes;Coles;Pharm. Res.,2008

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