Identification of a host cell protein impurity in therapeutic protein, P1

Author:

Ahluwalia Deepti,Dhillon Harbhajan,Slaney Thomas,Song Hangtian,Boux Heather,Mehta Sheetal,Zhang Lei,Valdez Anulfo,Krishnamurthy Girija

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference31 articles.

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2. Sustained productivity in recombinant Chinese hamster ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype;Meleady;BMC Biotechnol.,2011

3. Host cell protein testing by ELISAs and the use of orthogonal methods;Zhu-Shimoni;Biotechnol. Bioeng.,2014

4. Identification and Quantification of Heat-Shock Protein 70: A major host-cell protein contaminant from HEK host cells;Lu;Bioprocess Int.,2015

5. Fragmentation of a highly purified monoclonal antibody attributed to residual CHO cell protease activity;Gao;Biotechnol. Bioeng.,2011

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