HPLC–MS/MS method for the simultaneous quantification of desmethylmebeverine acid, mebeverine acid and mebeverine alcohol in human plasma along with its application to a pharmacokinetics study

Author:

Moskaleva Natalia E.,Baranov Pavel A.,Mesonzhnik Natalia V.,Appolonova Svetlana A.

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference14 articles.

1. Mebeverine, an effective agent in the irritable colon syndrome;Baume;Aust. N. Z. J. Med.,1972

2. A double-blind crossover comparison study of the safety and efficacy of mebeverine with mebeverine sustained release in the treatment of irritable bowel syndrome;Van-Outryve;J. Clin. Pharm. Ther.,1995

3. A comparison of mebeverine with high-fibre dietary advice and mebeverine plus ispaghula in the treatment of irritable bowel syndrome: an open prospectively randomised, parallel group study;Chapman;Br. J. Clin. Pract.,1990

4. Mebeverine alters small bowel motility in irritable bowel syndrome;Evans;Aliment. Pharmacol. Ther.,1996

5. Drug therapy options for patients with irritable bowel syndrome;Talley;Am. J. Manag. Care,2001

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