The metabolism of [14C]-zibotentan (ZD4054) in rat, dog and human, the loss of the radiolabel and the identification of an anomalous peak, derived from the animal feed-Reference-Cited by-同舟云学术

The metabolism of [14C]-zibotentan (ZD4054) in rat, dog and human, the loss of the radiolabel and the identification of an anomalous peak, derived from the animal feed

Published:2011-06 Issue:3 Volume:55 Page:500-517
ISSN:0731-7085
Container-title:Journal of Pharmaceutical and Biomedical Analysis
language:en
Short-container-title:Journal of Pharmaceutical and Biomedical Analysis

Author:

Lenz Eva M.,Kenyon Alison,Martin Scott,Temesi Dave,Clarkson-Jones Jacqueline,Tomkinson Helen

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

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3. Specific inhibition of the endothelin A receptor with ZD4054: clinical and pre-clinical evidence;Morris;Br. J. Cancer,2005

4. Endothelin-1 as a target for therapeutic intervention in prostate cancer;Kopetz;Invest. New Drugs,2002

5. A phase I study of zibotentan (ZD4054) in patients with metastatic, castrate-resistant prostate cancer;Schelman;Invest. New Drugs,2009

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