Modulation of the toxic and mutagenic effects induced by methyl methanesulfonate in Chinese hamster ovary cells by overexpression of the rat N-alkylpurine-DNA glycosylase

Author:

Calléja Fabienne,Jansen Jacob G,Vrieling Harry,Laval Françoise,van Zeeland Albert A

Publisher

Elsevier BV

Subject

Health, Toxicology and Mutagenesis,Genetics,Molecular Biology

Reference37 articles.

1. Quantitative comparison of genetic effects of ethylating agents on the basis of DNA-adduct formation. Use of O6-ethylguanine as molecular dosimeter for extrapolation from cells in culture to the mouse;van Zeeland;Environmental Health Perspectives,1985

2. A-T base pairs are the main target for mutations at the hprt locus of pouch skin fibroblasts of rats exposed in vitro to the monofunctional alkylating agent N-ethyl-N-nitrosourea;Jansen;Mutagenesis,1994

3. Marked differences in the role of O6-alkylguanine in hprt mutagenesis in T-lymphocytes of rats exposed in vivo to ethylmethanesulfonate, N-(2-hydroxyethyl)-N-nitrosourea, or N-ethyl-N-nitrosourea;Jansen;Cancer Res.,1995

4. Induction of hprt gene mutatons in splenic T-lymphocytes from the rat exposed in vivo to DNA methylating agents is correlated with formation of O6-methylguanine in bone marrow and not in the spleen;Jansen;Carcinogenesis,1996

5. The relation between reaction kinetics and mutagenic action of mono-functional alkylating agents in higher eukaryotic systems: I. Recessive lethal mutations and translocations in Drosophila;Vogel;Mutat. Res.,1979

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