The combination of UCN-01 and ATRA triggers differentiation in ATRA resistant acute promyelocytic leukemia cell lines via RAF-1 independent activation of MEK/ERK

Author:

Liang Cui,Ding Ming,Weng Xiang-qin,Sheng Yan,Wu Jing,Cai Xun

Funder

Natural Science Foundation of Shanghai

Publisher

Elsevier BV

Subject

Toxicology,General Medicine,Food Science

Reference58 articles.

1. Long-term outcome of acute promyelocytic leukemia treated with all- trans -retinoic acid , arsenic trioxide , and gemtuzumab;Abaza;Blood,2017

2. Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models;Akinaga;Cancer Res.,1991

3. Combination therapy with arsenic trioxide, all-trans retinoic acid, and gemtuzumab ozogamicin in recurrent acute promyelocytic leukemia;Aribi;Cancer,2007

4. Activation of extracellular signal-regulated kinases and CREB/ATF-1 mediate the expression of CCAAT/enhancer binding proteins β and -δ in preadipocytes;Belmonte;Mol. Endocrinol.,2001

5. The Raf/MEK inhibitor PD98059 enhances ERK1/2 phosphorylation mediated by peroxynitrite via enforced mitochondrial formation of reactive oxygen species;Cerioni;FEBS Lett.,2003

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