Mixture effects of food-relevant polycyclic aromatic hydrocarbons on the activation of nuclear receptors and gene expression, benzo[a]pyrene metabolite profile and DNA damage in HepaRG cells

Author:

Goedtke Lisa,John Andrea,Lampen Alfonso,Seidel Albrecht,Braeuning Albert,Hessel-Pras StefanieORCID

Funder

Bundesinstitut für Risikobewertung

Deutsche Forschungsgemeinschaft

Publisher

Elsevier BV

Subject

Toxicology,General Medicine,Food Science

Reference50 articles.

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2. DNA damage by benzo(a)pyrene in human cells is increased by cigarette smoke and decreased by a filter containing rosemary extract, which lowers free radicals;Alexandrov;Cancer Res.,2006

3. Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells;Aninat;Drug Metab. Dispos.,2006

4. Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and mechanism of action;Baird;Environ. Mol. Mutagen.,2005

5. Oxidation of benzo[a]pyrene by recombinant human cytochrome P450 enzymes;Bauer;Chem. Res. Toxicol.,1995

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