Cucurbitacin IIa interferes with EGFR-MAPK signaling pathway leads to proliferation inhibition in A549 cells

Author:

Zhang Jie,Song Yifan,Liang Yuan,Zou Haoyang,Zuo Peng,Yan Mi,Jing Siyuan,Li Tiezhu,Wang Yongjun,Li Da,Zhang Tiehua,Wei ZhengyiORCID

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

China Agricultural Research System

China Postdoctoral Science Foundation

Publisher

Elsevier BV

Subject

Toxicology,General Medicine,Food Science

Reference48 articles.

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2. The role of cucurbitacins in combating cancers: a mechanistic review;Alsayari;Pharm. Rev.,2018

3. The epidermal growth factor receptor: from mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia;Arteaga;J. Clin. Oncol.,2001

4. Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation;Boykin;Br. J. Canc.,2011

5. Stat3 as an oncogene;Bromberg;Cell,1999

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