Species differences between rat and human in vitro metabolite profile, in vivo predicted clearance, CYP450 inhibition and CYP450 isoforms that metabolize benzanthrone: Implications in risk assessment

Author:

Taneja Isha,Karsauliya Kajal,Rashid Mamunur,Sonkar Ashish Kumar,Rama Raju Kanumuri Siva,Singh Sandeep Kumar,Das Mukul,Wahajuddin Muhammad,Singh Sheelendra Pratap

Funder

Council of Scientific and Industrial Research

University Grants Commission

Publisher

Elsevier BV

Subject

Toxicology,General Medicine,Food Science

Reference22 articles.

1. In vivo prediction of CYP-mediated metabolic interaction potential of formononetin and biochanin A using in vitro human and rat CYP450 inhibition data;Arora;Toxicol. Lett.,2015

2. Introduction to in vitro estimation of metabolic stability and drug interactions of new chemical entities in drug discovery and development;Baranczewski;Pharmacol. Rep.,2006

3. On the incorporation of chemical-specific information in risk assessment;Clewell;Toxicol. Lett.,2008

4. Interaction of benzanthrone with cytochrome P450: altered patterns of hepatic xenobiotic metabolism in rats;Das;J. Biochem. Toxicol.,1991

5. Benzanthrone: a new substrate for hepatic microsomal cytochrome P-450;Das;Biochem. Int.,1989

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