A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial

Author:

Noor Nurulamin M,Lee James C,Bond Simon,Dowling Francis,Brezina Biljana,Patel Kamal V,Ahmad Tariq,Banim Paul J,Berrill James W,Cooney Rachel,De La Revilla Negro Juan,de Silva Shanika,Din Shahida,Durai Dharmaraj,Gordon John N,Irving Peter M,Johnson Matthew,Kent Alexandra J,Kok Klaartje B,Moran Gordon W,Mowat Craig,Patel Pritash,Probert Chris S,Raine Tim,Saich Rebecca,Seward Abigail,Sharpstone Dan,Smith Melissa A,Subramanian Sreedhar,Upponi Sara S,Wiles Alan,Williams Horace R T,van den Brink Gijs R,Vermeire Séverine,Jairath Vipul,D'Haens Geert R,McKinney Eoin F,Lyons Paul A,Lindsay James O,Kennedy Nicholas A,Smith Kenneth G C,Parkes Miles,Noor Nurulamin,Lee James,Bond Simon,Dowling Francis,Brezina Biljana,Patel Kamal,Ahmad Tariq,Banim Paul,Berrill James,Cooney Rachel,De La Revilla Negro Juan,de Silva Shanika,Din Shahida,Durai Dharmaraj,Gordon John,Irving Peter,Johnson Matthew,Kent Alexandra,Kok Klaartje Bel,Moran Gordon,Mowat Craig,Patel Pritash,Probert Chris,Raine Tim,Saich Rebecca,Seward Abigail,Sharpstone Dan,Smith Melissa,Subramanian Sreedhar,Upponi Sara,Wiles Alan,Williams Horace,van Den Brink Gijs,Vermeire Severine,Jairath Vipul,D'Haens Geert,McKinney Eoin,Lyons Paul,Lindsay James,Kennedy Nicholas,Smith Kenneth,Parkes Miles,Allcock Clare,Bhatti Suhaylah,Blackwell Jonathan,Boulton-Jones Robert,Brookes Matthew,Butcher Rhys,Butterworth Jeffrey,Champion Karlena,Chaudhary Rakesh,Cole Andy,Derikx Lauranne,Dhar Anjan,Flowerdew Mary,Goel Rishi,Hart Ailsa,Hughes Rory,Javaid Babur,Knight Paul,Lee Jacinta,Lees Charlie,Levell Emma,Li Andy,Murray Charles,O'Brien Leisha,Parkes Gareth,Pollok Richard,Powles Sam,Ramdas Arvind,Smith Philip,Speight Richard Ally,Travis Simon,Weaver Sean,Wesley Emma

Funder

University Hospitals Bristol NHS Foundation Trust

University of Cambridge

Wellcome Trust

Publisher

Elsevier BV

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