Influenza virus carrying neuraminidase with reduced sensitivity to oseltamivir carboxylate has altered properties in vitro and is compromised for infectivity and replicative ability in vivo

Author:

Carr J,Ives J,Kelly L,Lambkin R,Oxford J,Mendel D,Tai L,Roberts N

Publisher

Elsevier BV

Subject

Virology,Pharmacology

Reference24 articles.

1. Bantia, S., Ananth, S., Horn, L., Parker, C., Gulati, U., Chand, P., Babu, Y., Air, G., 2000. Generation and characterisation of a mutant of influenza A virus selected with the neuraminidase inhibitor RWJ-270201. Antiviral Res. 46 A1–A90, A82.

2. Carr, J., Ives, J., Roberts, N., Kelly, L., Lambkin, R., Oxford, J., Tai, C.Y., Mendel, D., Hayden, F., 2000. Virological assessment in vitro and in vivo of an influenza H1N1 virus with a H274Y mutation in the neuraminidase gene. Antiviral Res. 46 A1–A90, A79.

3. Carr, J., Ives, J., Gibson, V., Clark, L., Elias, S., Harrison, S., Roberts, N., Herlocher, L., Monto, A., 2001. Influenza virus carrying an R292K mutation in the neuraminidase gene is not transmitted in ferrets. Antiviral Res. 50 A1–A94, A162.

4. Influenza virus neuraminidase: structure, antibodies, and inhibitors;Colman;Protein Sci.,1994

5. Phenotypic and genotypic assay of influenza virus neuraminidase indicates a low incidence of viral drug resistance during treatment with oseltamivir;Covington;J. Clin. Virol.,2000

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