Combinations of reverse transcriptase, protease, and integrase inhibitors can be synergistic in vitro against drug-sensitive and RT inhibitor-resistant molecular clones of HIV-1

Author:

Beale Keola K.,Robinson W.Edward

Publisher

Elsevier BV

Subject

Virology,Pharmacology

Reference47 articles.

1. Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease;Autran;Science,1997

2. Structural basis of drug resistance for the V82A mutant of HIV-1 proteinase;Baldwin;Nat. Struct. Biol.,1995

3. Combination therapy for infection due to human immunodeficiency virus type 1;Caliendo;Clin. Infect. Dis.,1994

4. Relationships between inhibition constants and fractional inhibitions in enzyme-catalyzed reactions with different numbers of reactants, different reaction mechanisms, and different types of mechanisms of inhibition;Chou;Mol. Pharmacol.,1974

5. The median-effect principle and the combination index for quantitation of synergism and antagonism;Chou,1991

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