Efficacy and safety of anti-amyloid-β monoclonal antibodies in current Alzheimer's disease phase III clinical trials: A systematic review and interactive web app-based meta-analysis

Author:

Jeremic Danko,Navarro-López Juan D.,Jiménez-Díaz Lydia

Funder

Universidad de Castilla-La Mancha

European Regional Development Fund

European Social Fund

Junta de Comunidades de Castilla-La Mancha

Publisher

Elsevier BV

Subject

Neurology,Molecular Biology,Aging,Biochemistry,Biotechnology

Reference47 articles.

1. Alzforum, 2023a. Aduhelm, https://www.alzforum.org/therapeutics/aduhelm.

2. Alzforum, 2023b. Leqembi, https://www.alzforum.org/therapeutics/leqembi.

3. Effects of monoclonal antibodies against amyloid-β on clinical and biomarker outcomes and adverse event risks: a systematic review and meta-analysis of phase III RCTs in Alzheimer's disease;Avgerinos;Ageing Res Rev.,2021

4. Borenstein, M., Hedges, L.V., Higgins, J.P., Rothstein, H.R., 2021. Introduction to meta-analysis, 2nd ed. John Wiley & Sons.

5. Two randomized phase 3 studies of aducanumab in early Alzheimer's disease;Budd Haeberlein;J. Prev. Alzheimers Dis.,2022

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